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BeyondSpring’s Lead Asset, Plinabulin, Shifts the Balance of Macrophages Towards Anti-Cancer M1s
Tumor-associated macrophages are believed to play an important role in the growth, progression and metastasis of tumors. While macrophages with an M1 phenotype have anti-cancer functions, M2 macrophages are thought to support tumor cell survival and metastasis. Having the ability to increase M1 and/or reduce M2 macrophages may help the immune system to slow the growth of tumors or reject tumors. Collaborators of
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Dr. Zippelius and Dr Kashyap from the
“Shifting the M1/M2 ratio to a predominant M1 phenotype can shift the balance from an immune-suppressive to an immune-enhancing tumor microenvironment (TME). Checkpoint inhibitors (PD1/PD-L1- and CTLA4-inhibitors), although very effective, over time often lose their efficacy due to resistance development. Tumor-associated macrophages (TAMs) of the M2 phenotype contribute to an immune-suppressive TME that may induce resistance to checkpoint inhibitor therapy. The finding of Plinabulin’s ability to improve the M1/M2 balance, along with the prior demonstration of increased dendritic cell maturation with Plinabulin treatment, support the potential utility of adding Plinabulin to established checkpoint-inhibitor therapy to increase potency, and to potentially reverse resistance to these checkpoint inhibitors. Early stage clinical trials are underway to test these new strategies,” added Dr.
The AACR Annual Meeting will take place from
Cautionary Note Regarding Forward-Looking Statements