|View printer-friendly version|
Study Opens of BeyondSpring’s Lead Asset, Plinabulin, and Nivolumab + Ipilimumab in Small-Cell Lung Cancer
Rutgers Trial Aims to Demonstrate Reduction in Immune-Related Adverse Events, While Adding to Anti-Cancer Immune Effects for Patients
“Our collective mission is to bring the best possible therapy to SCLC patients around the world as quickly and efficiently as we can,” said Dr. Malhotra. “There is a need to explore novel immunotherapy combinations with the goal of improving clinical outcomes as well as reducing side effects.”
Approximately 10 to 15 percent of lung cancers are SCLC. Although it is less common than non- small cell lung cancer (NSCLC), SCLC is more aggressive, as these cancer cells tend to grow rapidly and metastasize more easily. Related to this, SCLC symptoms usually do not surface in patients until the cancer has progressed to a more advanced stage, setting a higher bar for therapeutic benefit.
Plinabulin is a novel small molecule with immune-enhancing effects and anti-cancer activity that induces dendritic cell maturation and T-cell activation. Plinabulin is in advanced Phase 3 testing to both increase the potency of standard-of-care chemotherapy (i.e., docetaxel), while at the same time alleviating chemotherapy-induced side effects. The aim of the present triple combination study is to accomplish similar goals with the standard-of-care immuno-oncology (I/O) therapies by reducing treatment-related side effects and increasing the therapeutic benefit to patients.
“Given that Plinabulin is also in Phase 3 clinical trials for both NSCLC treatment and the prevention of chemotherapy-induced neutropenia, this drug candidate is an I/O molecule with multiple possible indications,” concluded Dr.
Cautionary Note Regarding Forward-Looking Statements