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Plinabulin Newly Granted Patent Covering Method of Use in Prevention of Neutropenia
The patent covers methods for Plinabulin’s use in treating or reducing the incidence of grade 3 or 4 CIN in patients who are being treated with taxane, including instances where the taxane is docetaxel, with patent protection until 2033 in
“Plinabulin already has over 70 patents granted in 34 countries, covering its composition of matter and method of use in cancer treatment. The issuance of this patent provides us with expanded freedom to operate and greater flexibility to extend our development and commercialization plan to the Japanese market,” said Dr. Huang. “Not only does this patent add to our already robust global patent portfolio for Plinabulin, it also provides us with greater opportunity to reach a large patient population in
Plinabulin is currently in Phase 3 global clinical development for the prevention of CIN.
About Chemotherapy-Induced Neutropenia
The current standard of care for chemotherapy-induced neutropenia prevention is G-CSF monotherapy. However, G-CSF monotherapy has limitations as described in its product information summary. As many as 90 percent of patients on chemotherapy and G-CSF monotherapy may still experience grade 3/4 neutropenia. NCCN guidelines require that patients with grade 3/4 neutropenia decrease chemotherapy dose intensity, delay chemotherapy cycle timing or discontinue chemotherapy, each of which can have a negative effect on the long-term outcomes of cancer care.
Cautionary Note Regarding Forward-Looking Statements